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Scientists Reverse Brain Damage In Drowned U.S Toddler Eden Carlson Using Oxygen Therapy

In what is believed to be a first ever in this world when scientists reversed brain damage in a toddler that drowned in a swimming pool. With the aid of Oxygen Therapy, scientists were given the opportunity to restore Eden Carlson's ability to walk and talk just a few months after the accident, in which she spent 15 minutes submerged in a swimming pool and two hours where her heart did not beat on its own.

The fatal accident took place in February of 2016. Two-year-old Eden Carlson somehow managed to maneuver through the baby gate and fall into the family swimming pool and was in the 5 degree Celsius water for up to 15 minutes before being found.

After being resuscitated and treated in hospital for just over a month, she was unresponsive to all stimuli. In addition, Eden was immobile and constantly squirmed and shook her head. MRI scans displayed deep injury to the brain’s gray matter, as well as loss of white and gray matter.

In an effort to reverse the brain damage, researchers at the LSU Health New Orleans School of Medicine and the University of North Dakota School of Medicine started treating Eden with two different types of oxygen therapy.

These to oxygen therapies included:

Normobaric Oxygen Therapy: where levels of oxygen given are the same as at sea level, and hyperbaric oxygen therapy (HBOT), where they are given pure oxygen at pressures higher than that of the atmosphere within a special chamber.

Fifty five days after the drowning accident, doctors began giving her normobaric oxygen for 45 minutes twice per day. At times, this appeared to make her more alert and awake, and she stopped squirming. As a result, she also began laughing more and was able to move her arms and hands, and grasp with her left. Scientists also noted eye-tracking movements and some speech.

After 78 days, Eden started hyperbaric oxygen therapy (HBOT), with 45 minute sessions five days per week for four weeks.

After 10 sessions, her mother said she was almost back to normal other than motor function.

After 39 sessions—coupled with physical therapy — Eden was able to walk and her speech had returned to normal. Furthermore, her cognitive abilities had improved and motor function was almost restored to pre-drowning levels.

An MRI scan a month after the 40th HBOT session displayed almost complete reversal of the brain damage initially recorded. Researchers strongly believe the oxygen therapy, coupled with Eden having the developing brain of a child, had activated genes that easily promoted cell survival and reduce inflammation — giving the brain an opportunity to recover quicker. The case report is published in the journal Medical Gas Research.

Paul Harch, who treated Eden, said in a statement:

“The startling regrowth of tissue in this case occurred because we were able to intervene early in a growing child, before long-term tissue degeneration. Although it’s impossible to conclude from this single case if the sequential application of normobaric oxygen then HBOT would be more effective than HBOT alone, in the absence of HBOT therapy, short duration, repetitive normobaric oxygen therapy may be an option until HBOT is available."

In conclusion

The researchers say that to their knowledge, this is the first reported case of gray matter loss and white matter atrophy (types of brain damage) reversal with any therapy and that treatment with oxygen should be considered in similar cases. “Such low-risk medical treatment may have a profound effect on recovery of function in similar patients who are neurologically devastated by drowning."

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